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The Office of Entrepreneurship and Innovation at the University CES is part of   the Knowledge Management Direction, and provides university members with consulting for the generation and implementation of innovative ideas, support for the creation of technology-based companies, entrepreneurship training, assistance to find resources for entrepreneurship and specialized counseling. This Office also accompanies the entire process of companies based on research technology results, which at the end are business units of the university, known as Spin Off.

Additionally, the Office, has been articulated to the city networks, which promotes the strengthening of the Entrepreneurship Ecosystem City: The City Program E (Mayoralty of Medellin - Comfama), Red Motiva and the Entrepreneurship Park.